In our opinion, the best nootropic supplement of Alpha GPC in 2021 for personal use is the Cofttek Alpha GPC. The best thing about this supplement is that it is a vegetarian/vegan product and thus, everyone can take it. More importantly, the supplement does not contain any wheat, gluten, dairy, egg, fish, and nuts. It, therefore, is also suitable for consumption for people with allergies. However, if you have any preexisting conditions, you must speak with your doctor first. This supplement has garnered only positive reviews and does exactly what it claims to do.

Alpha GPC FAQ:

What is Alpha GPC good for?

Alpha GPC administration increases the release of the neurotransmitter acetylcholine and facilitates learning and memory. In athletes, Alpha GPC supplementation prevents exercise-induced reductions in choline levels, increases endurance performance and growth hormone secretion.

How long does it take for Alpha GPC to work?

Alpha GPC is effective at increasing lower body force production after 6 days of supplementation. Sport performance coaches can consider adding Alpha GPC to the diet of speed and power athletes to enhance muscle performance.

Does Alpha GPC make you tired?

It does make you more tired at night, but this makes sense because of the higher quality work your mind did during the day. And of course, you need to sleep to let your mind fully process the memories you made all day long.

Does Alpha brain have side effects? 

The side effects of Alpha Brain is very rare. Based on Alpha Brain clinical trial and evidence, there is no report on adverse effects of the supplement.

Can you have too much choline? 

Getting too much choline can cause a fishy body odor, vomiting, heavy sweating and salivation, low blood pressure, and liver damage. Some research also suggests that high amounts of choline may increase the risk of heart disease.

Can you take Alpha GPC and CDP choline together? 

These two choline supplements work well together. … Alpha GPC is a byproduct of phosphatidylcholine (PC). And supplemental CDP Choline provides the uridine needed for PC synthesis. So taken together, you provide your brain with the type of choline it needs right down at the cellular level.

Is Alpha GPC natural?

Alpha GPC is a naturally occurring molecule that resides within the brain. This vital nutrient, closely related to the B-vitamin family, specifically resides within the cell membrane neurons.

Is Alpha brain safe?

Alpha Brain is one of the safest nootropic supplements. However, you may experience some minor side effects in terms of medicine interactions or when consuming more than required. That is why you must stick to the recommended dosage and must consult with your doctor before taking any nootropic supplement

How long do the effects of Alpha brain last?

Alpha Brain lasts more than 6 hours. According to some of the independent reviews on Alpha Brain, the effects may last more than 7-8 hours.

Does Alpha brain really work?

The use of Alpha brain for 6-weeks significantly improved recent verbal memory and executive function when compared with controls, in a group of healthy adults aged 18-35. Results of this trial merit further study toward the application of cognitive enhancing supplements in athletic performance.

Does Joe Rogan own Alpha brain? 

Joe Rogan is affiliated with a company called Onnit, which creates Alpha Brain, a product meant to improve verbal recall and task completion. Alpha Brain is also one of the few products on the market that does have clinical trials and Rogan believes it helps him recall words and phrases better than a placebo.

Is Alpha brain legal?

Commenting on this situation, founder of Onnit Aubrey Marcus said: “We can say unequivocally that there are no amphetamines or other banned substances in Alpha brain. We electively test every batch of Alpha brain at our own expense to ensure that our products are free of any banned or illegal substances.

What is the best Nootropic supplement?

Alpha GPC is a naturally-existing choline compound found in the brain. This compound is also released when a fatty acid found in soy and other plants breaks down. Though Alpha GPC exists naturally, in its natural concentration and quantity, it is not enough to perform the functions it is designed to support. Thus, Alpha GPC is often prescribed for consumption in the form of dietary supplements that contain Alpha GPC produced through either chemical or enzymatic deacylation of phosphatidylcholine-enriched soya phospholipids.

The research done on Alpha GPC over the years has established it as a parasympathomimetic acetylcholine precursor that stimulates the parasympathetic nervous system and therefore, actively helps with the treatment of Alzheimer’s and different forms of dementia. Alpha GPC is also the most efficient choline prodrug and thus, supplements containing this compound serve as a source of dietary choline. Choline is an essential nutrient that the body needs to perform several essential functions, such as cellular growth and metabolism. Alpha GPC is also an effective nootropic that enhances the brain’s cognitive function. It is thus often prescribed to elderly patients experiencing cognitive decline. Alpha GPC intake can also increase the production of the growth hormone within the body and thus, athletes around the work use Alpha GPC supplements to enhance their overall power output.

What is the best brain supplement? 

Alpha GPC supplements bring with them several possible benefits. To start with, Alpha GPC is known to improve brain health and function. It does so by increasing dopamine levels with the body. Several studies have also linked this compound with improved memory function and learning ability. In some particular cases, alpha GPC supplements have also been able to restore memory though such cases are far and few. Other than improving brain and cognitive functions, there is enough evidence to prove that Alpha GPC can be used to treat Alzheimer’s, different forms of dementia, and transient ischemic attacks. The compound is also used by athletes as it boosts their performance output. In conclusion, alpha GPC has several established benefits, a key factor that has added to its popularity in recent years.

Does Alpha GPC increase HGH?

Alpha GPC is a putative acetylcholine precursor that potentially increases growth hormone secretion through the action of acetylcholine-stimulated catecholamine.

Does choline cause depression?

We found no significant associations in the corresponding analyses of the relation between plasma choline and depression symptoms. In this large population–based study, choline concentrations were negatively associated with anxiety symptoms but not with depression symptoms.

What does Alpha brain contain?

Alpha Brain has two ingredients that boost acetylcholine levels: GPC choline, which the body converts to acetylcholine, and Huperzine A, an alkaloid derived from Chinese club moss, also known as Huperzia serrata.

Is CDP choline safe?

CDP choline is a safe drug, as toxicological tests have shown; it has no serious effects on the cholinergic system and it is perfectly tolerated.

What are the effects of Noopept?

Possible side effects of noopept included sleep disturbances (5/31 patients), irritability (3/31), and increased blood pressure (7/31) (Neznamov and Teleshova, 2009). Mechanisms of action from preclinical research One study in rodents reported that noopept crossed the blood brain barrier.

Does Alpha GPC increase dopamine?

It may be possible for Alpha GPC to improve memory formation and enhance learning ability. Alpha GPC can also raise dopamine levels, which benefits brain function significantly.

How fast does Alpha GPC work?

Alpha GPC is effective at increasing lower body force production after 6 days of supplementation. Sport performance coaches can consider adding Alpha GPC to the diet of speed and power athletes to enhance muscle performance.

What are the symptoms of choline deficiency?

  • Feeling anxious or restless.
  • Fatty liver, otherwise known as non-alcoholic fatty liver disease (NAFLD)
  • Muscle damage.
  • Hyperhomocysteinemia.
  • Hemorrhagic kidney necrosis.
  • Cancer.

Is choline good for anxiety? 

Choline may boost memory function, improve brain development and treat anxiety and other mental disorders.

What is the best source of choline?

The richest dietary sources of choline are meat, fish, dairy, and eggs. Many fruits, vegetables, and whole grains contain choline as well, so there are plenty of options for people on vegetarian or plant-based diets.

How can I get choline naturally? 

Multivitamins do not typically contain choline.

Although foods rich in choline—liver, egg yolks, and red meat—tend to be higher in saturated fat, choline can also be found in foods lower in saturated fat including salmon, cod, tilapia, chicken breast, and legumes.

How do you test for choline deficiency?

At present, there is no definitive clinical test that can be used to identify persons who are choline deficient. Plasma choline, betaine, and phosphatidylcholine concentrations decreased in humans fed a choline-deficient diet, but they plateau after falling 30%–50%.

What does Alpha GPC taste like?

It has a slightly sweet flavor to it which can only be subtly noticed. It’s definitely not a sugar substitute for everybody.

Are choline supplements effective?

Large observational studies link choline intake and blood levels to improved brain function, including better memory and processing. Supplementing with 1,000 mg per day led to improved short- and long-term verbal memory in adults aged 50–85 who had poor memory.

Is citicoline the same as choline?

Citicoline is the ingredient name for a compound that’s chemically identical to cytidine-diphosphocholine (CDP choline). The only difference is that CDP choline is naturally occurring in humans, and citicoline is the form found in nutritional supplements.

Does citicoline increase dopamine?

Citicoline enhances cellular communication by increasing the availability of neurotransmitters, including acetylcholine, norepinephrine, and dopamine. In simple terms, the choline component of citicoline is used to create acetylcholine, which is a primary executive neurotransmitter in the human brain.

What is the difference between choline and phosphatidylcholine?

Phosphatidylcholine is a chemical contained in eggs, soybeans, mustard, sunflower, and other foods. The term “phosphatidylcholine” is sometimes used interchangeably with “lecithin,” although the two are different. Choline is a component of phosphatidylcholine, which is a component of lecithin.

Does choline cause anxiety?

In this large population–based study, choline concentrations were negatively associated with anxiety symptoms but not with depression symptoms.

Does choline increase serotonin?

Changes in plasma levels of choline or of certain amino acids lead to changes in brain levels of the precursors for these neurotransmitters—choline for acetylcholine, tryptophan for serotonin, and tyrosine for the catecholamines.

What are the side effects of choline?

  • hypotension.
  • sweating.
  • vomiting.
  • excessive salivation.
  • liver toxicity.
  • a fishy body odor.

Does choline give you energy?

It’s reported that choline plays an important role in the metabolism of fat; it breaks fat down for use as an energy source. This action of choline makes it valuable in preventing conditions like fatty liver or excess fat in the blood.

Is Lecithin good for anxiety?

Lecithin is used for treating memory disorders such as dementia and Alzheimer’s disease. It is also used for treating gallbladder disease, liver disease, certain types of depression, high cholesterol, anxiety, and a skin disease called eczema.

What are the side effects of Alpha GPC?

It can cause side effects in some people including heartburn, headache, dizziness, and skin rash. When given as a shot: Alpha GPC is POSSIBLY SAFE when used appropriately. It can cause side effects in some people including heartburn, headache, insomnia, confusion, and redness at the injection site.

How long does it take Alpha GPC to work?

Alpha GPC is effective at increasing lower body force production after 6 days of supplementation. Sport performance coaches can consider adding Alpha GPC to the diet of speed and power athletes to enhance muscle performance.

Is Alpha GPC water or fat soluble?

The most common forms in the diet are phosphatidylcholine (PC), phosphocholine, alpha-gpc, sphingomyelin, CDP-choline, and free choline. Phospholine, free choline, and alpha-gpc are water-soluble, while phosphatidylcholine and sphingomyelin are fat-soluble.

Is Alpha brain safe to use?

Alpha Brain is one of the safest nootropic supplements. However, you may experience some minor side effects in terms of medicine interactions or when consuming more than required. That is why you must stick to the recommended dosage and must consult with your doctor before taking any nootropic supplement.

Does brain supplements work?

All the studies conducted to analyse different effects of Alpha GPC on various bodily functions unanimously agree that the compound, when consumed within its daily limits, is entirely safe. However, excessive intake of Alpha GPC can lead to side-effects, such as headache, heartburn, insomnia and dizziness. More importantly, pregnant and breast-feeding women must not consume this compound as no study has been done so far to study the effect of Alpha GPC on pregnant women. Similarly, if you have a pre-existing condition, it is best to consult with your doctor before starting with any Alpha GPC supplement.

Can Nootropics cause headaches? 

But there are some potential side effects, including headaches, anxiety and insomnia.

Can too much choline be harmful?

Getting too much choline can cause a fishy body odor, vomiting, heavy sweating and salivation, low blood pressure, and liver damage. Some research also suggests that high amounts of choline may increase the risk of heart disease.

Can you take Alpha GPC every day?

When taken at recommended dosages Alpha GPC is well tolerated. For most adults the range of acceptable dosage is relatively broad; a cumulative daily dosage of 300-1200 mg, when taken in one or two doses, is safe and efficient.

Are Nootropics safe?

The misuse of nootropics—any substance that may alter, improve, or augment cognitive performance, mainly through the stimulation or inhibition of certain neurotransmitters—may potentially be dangerous and deleterious to the human brain, and certain individuals with a history of mental or substance use disorders might.

What is the best brain pill on the market?

In the last few years, people have started paying more attention to their bodies. The conversation around brain health has intensified significantly as the brain serves as the control centre for the entire body and any malfunctioning in the brain can lead to dire implications. Choline plays a crucial role in maintaining brain health and improving brain function. Thus, many dietary supplements now include compounds that provide choline to the body. One such compound is Alpha GPC.

Is Coffee a Nootropic?

Coffee is considered a nootropic because it contains caffeine. Caffeine is a popular nootropic that primarily enhances alertness and mood. Nootropics, also widely called “smart drugs” helps improve cognitive functions, enhances memory and brain performance.

Which Nootropics actually work?

A study done to understand the effect of alpha GPC on power output revealed that a dosage of 600 mg causes an increase in the secretion of the growth hormone. Thus, a standard dosage of alpha GPC is usually between 300 to 600 mg and athletes are advised to stick to the upper limit.

However, when it comes to treating cognitive decline, almost all studies that analyzed the effect of Alpha GPC on the cognitive function used a standard dosage of 1200 mg per day, divided into three doses of 400 mg. A decrease in this dosage amount may not have the same effect as a 1200 mg dosage per day. Thus, patients suffering from Alzheimer’s, dementia, and TIA are often advised to stick to the 1200mg/day dosage.

Is CBD a Nootropic?

Because of its wide range of cognitive health benefits, CBD is considered a nootropic. Many researchers are enthusiastic about CBD’s potential to help with common mental challenges such as anxiety, depression, and stress.

What are the Benefits of Alpha GPC?

 It’s Effective in Treating Alzheimer’s Disese

Over the years several studies have been conducted to study the ability of this compound to aid with the treatment of Alzheimer’s. One such study revealed that Alpha GPC enhances the level of acetylcholine in the brain. Acetylcholine is linked with enhanced brain function and improved cognition. More importantly, the study also revealed that in people with hypertension, Alpha GPC reduced inflammation around blood vessels in the brain, thereby leading to improved brain function.

Research has also shown that patients suffering from Alzheimer’s disease can benefit from taking 1200 mg of alpha GPC daily. This dosage is recommended for a duration of 3 to 6 months and significantly improves thinking skills of people suffering from this lethal disease.

 It Helps with the Treatment of Dementia

Many people get confused between dementia and Alzheimers. So, it is essential to establish the difference between the two first. Dementia is a general term used to describe a decline in a person’s mental ability to an extent that the decline begins to interfere with the person’s day-to-day tasks. Alzheimer’s is not dementia but a specific disease that is one of the most common causes of dementia.

Over the years, several studies have been conducted to study the effect of alpha GPC intake on dementia patients. One study revealed that regular alpha GPC intake over six months improved cognition and function in patients with mild to moderate dementia. Similarly, another study linked regular alpha GPC consumption with improved cognition in patients suffering from dementia and cerebrovascular disease. In conclusion, people suffering from dementia can benefit immensely from taking 1000 mg of Alpha GPC per day dosage. In such patients, Alpha GPC intake is linked with improved behaviour, mood, and cognition.

It Is Used to Treat Transient Ischemic Attacks

Transient ischemic attacks (TIA) are brief episodes of neurological dysfunction, often caused by an interruption to the supply of blood to the brain and eye. Transient ischemic attacks usually last for only a few minutes but they are seen as precursors of stroke. A study was conducted to study the effect of Alpha GPC on stroke and TIA patients. The study revealed that people who took 1200-mg Alpha GPC shots every day for 28 days, followed by 1200 mg/day of Alpha GPC (through oral measures) for six months, showed better-thinking skills and as well as better recovery from TIA.

 It Makes an Effective Nootropic Supplement

Acetylcholine is an organic chemical that works as a neurotransmitter and is crucial for memory and learning functions. Alpha GPC increases this chemical within the brain, thereby leading to enhanced memory and cognition. Thus, alpha GPC is often used as a key component in nootropic dietary supplements.

 It Improves Athletic Performance

In athletes, alpha GPC intake is linked with an exercise-induced reduction in choline. More importantly, it is also linked with increased growth hormone production and enhanced endurance performance. Thus, coaches and trainers often advice athletes to consume alpha GPC to achieve enhanced muscle performance.

What Is Alpha GPC?

Alpha GPC or L-Alpha Glycerlphosphorylcholine or Choline Alfoscerate is a naturally-existing choline compound found in the brain. This compound is also released when a fatty acid found in soy and other plants breaks down. Though Alpha GPC exists naturally, in its natural concentration and quantity, it is not enough to perform the functions it is designed to support. Thus, Alpha GPC is often prescribed for consumption in the form of dietary supplements that contain Alpha GPC produced through either chemical or enzymatic deacylation of phosphatidylcholine-enriched soya phospholipids.

The research done on Alpha GPC over the years has established it as a parasympathomimetic acetylcholine precursor that stimulates the parasympathetic nervous system and therefore, actively helps with the treatment of Alzheimer’s and different forms of dementia. Alpha GPC is also the most efficient choline prodrug and thus, supplements containing this compound serve as a source of dietary choline. Choline is an essential nutrient that the body needs to perform several essential functions, such as cellular growth and metabolism. Alpha GPC is also an effective nootropic that enhances the brain’s cognitive function. It is thus often prescribed to elderly patients experiencing cognitive decline. Alpha GPC intake can also increase the production of the growth hormone within the body and thus, athletes around the work use Alpha GPC supplements to enhance their overall power output.

In this article, we discuss key aspects of this compound, including Alpha GPC benefits, correct dosage, best Alpha GPC supplement currently available in the market and where can one buy this powder in bulk.


Why We Need Alpha GPC

In the last few years, people have started paying more attention to their bodies. The conversation around brain health has intensified significantly as the brain serves as the control centre for the entire body and any malfunctioning in the brain can lead to dire implications. Choline plays a crucial role in maintaining brain health and improving brain function. Thus, many dietary supplements now include compounds that provide choline to the body. One such compound is Alpha GPC.

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Alpha GPC Uses

Alpha GPC supplements bring with them several possible benefits. To start with, Alpha GPC is known to improve brain health and function. It does so by increasing dopamine levels with the body. Several studies have also linked this compound with improved memory function and learning ability. In some particular cases, alpha GPC supplements have also been able to restore memory though such cases are far and few. Other than improving brain and cognitive functions, there is enough evidence to prove that Alpha GPC can be used to treat Alzheimer’s, different forms of dementia, and transient ischemic attacks. The compound is also used by athletes as it boosts their performance output. In conclusion, alpha GPC has several established benefits, a key factor that has added to its popularity in recent years.

Alpha GPC Benefits

Alpha GPC supplements have gained such tremendous popularity owing to the compound’s ability to help the body recover from several impairments. In this part, we discuss some established uses of Alpha GPC Benefits.

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① It’s Effective in Treating Alzheimer’s Disese

Over the years several studies have been conducted to study the ability of this compound to aid with the treatment of Alzheimer’s. One such study revealed that Alpha GPC enhances the level of acetylcholine in the brain. Acetylcholine is linked with enhanced brain function and improved cognition. More importantly, the study also revealed that in people with hypertension, Alpha GPC reduced inflammation around blood vessels in the brain, thereby leading to improved brain function.

Research has also shown that patients suffering from Alzheimer’s disease can benefit from taking 1200 mg of alpha GPC daily. This dosage is recommended for a duration of 3 to 6 months and significantly improves thinking skills of people suffering from this lethal disease.(2). Doggrell SA & Evans S; Evans (Oct. 2003).

② It Helps with the Treatment of Dementia

Many people get confused between dementia and Alzheimers. So, it is essential to establish the difference between the two first. Dementia is a general term used to describe a decline in a person’s mental ability to an extent that the decline begins to interfere with the person’s day-to-day tasks. Alzheimer’s is not dementia but a specific disease that is one of the most common causes of dementia.

Over the years, several studies have been conducted to study the effect of alpha GPC intake on dementia patients. One study revealed that regular alpha GPC intake over six months improved cognition and function in patients with mild to moderate dementia. Similarly, another study linked regular alpha GPC consumption with improved cognition in patients suffering from dementia and cerebrovascular disease. In conclusion, people suffering from dementia can benefit immensely from taking 1000 mg of Alpha GPC per day dosage. In such patients, Alpha GPC intake is linked with improved behaviour, mood, and cognition.

③ It Is Used to Treat Transient Ischemic Attacks

Transient ischemic attacks (TIA) are brief episodes of neurological dysfunction, often caused by an interruption to the supply of blood to the brain and eye. Transient ischemic attacks usually last for only a few minutes but they are seen as precursors of stroke. A study was conducted to study the effect of Alpha GPC on stroke and TIA patients. The study revealed that people who took 1200-mg Alpha GPC shots every day for 28 days, followed by 1200 mg/day of Alpha GPC (through oral measures) for six months, showed better-thinking skills and as well as better recovery from TIA.

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④ It Makes an Effective Nootropic Supplement

Acetylcholine is an organic chemical that works as a neurotransmitter and is crucial for memory and learning functions. Alpha GPC increases this chemical within the brain, thereby leading to enhanced memory and cognition. Thus, alpha GPC is often used as a key component in nootropic dietary supplements.

⑤ It Improves Athletic Performance

In athletes, alpha GPC intake is linked with an exercise-induced reduction in choline. More importantly, it is also linked with increased growth hormone production and enhanced endurance performance. Thus, coaches and trainers often advice athletes to consume alpha GPC to achieve enhanced muscle performance.

Alpha GPC Dosage

A study done to understand the effect of alpha GPC on power output revealed that a dosage of 600 mg causes an increase in the secretion of the growth hormone. Thus, a standard dosage of alpha GPC is usually between 300 to 600 mg and athletes are advised to stick to the upper limit.

However, when it comes to treating cognitive decline, almost all studies that analyzed the effect of Alpha GPC on the cognitive function used a standard dosage of 1200 mg per day, divided into three doses of 400 mg. A decrease in this dosage amount may not have the same effect as a 1200 mg dosage per day. Thus, patients suffering from Alzheimer’s, dementia, and TIA are often advised to stick to the 1200mg/day dosage.

Is Alpha GPC Safe?

All the studies conducted to analyse different effects of Alpha GPC on various bodily functions unanimously agree that the compound, when consumed within its daily limits, is entirely safe. However, excessive intake of Alpha GPC can lead to side-effects, such as headache, heartburn, insomnia and dizziness. More importantly, pregnant and breast-feeding women must not consume this compound as no study has been done so far to study the effect of Alpha GPC on pregnant women. Similarly, if you have a pre-existing condition, it is best to consult with your doctor before starting with any Alpha GPC supplement.

Where to Buy Alpha GPC Powder in Bulk?

If you are a company that manufactures Alpha GPC supplements or an individual who understand its many benefits and therefore, have committed yourself fully to it, you may feel the need to buy Alpha GPC powder in bulk. The supplements available in the market tend to be on the expensive side and are only enough to last a few weeks. If you want to buy Alpha GPC in bulk, the best place to shop is Cofttek.

Cofttek is a supplement raw material manufacturer that entered the market in 2008 and has established its presence around the globe in only a few years. The company has created a name for itself through its high-quality products. Today, the company supplies products to pharmaceutical companies in North America, Europe, India and China. The Alpha GPC provided by Cofttek is a high-quality product that just lasts forever. So, if you need Alpha GPC in bulk, the best place to shop is here:product-28319-77-9 

Article by:Dr. Zeng

Article by:

Dr. Zeng

Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic chemistry and drug design synthesis; nearly 10 research papers published in authoritative journals, with more than five Chinese patents.

References

(1). US National Library of Medicine National Institute of Health, Gatti G, Barzaghi N, Acuto G, Abbiati G, Fossati T, Perucca E., 1992 Sep;30(9):331-5.

(2). Doggrell SA & Evans S; Evans (Oct. 2003). “Treatment of dementia with neurotransmission modulation”. Expert Opinion Investigating Drugs. 12 (10): 1633–1654.

(3). Parnetti, Lucilla; et al. (2007). “Cholinergic precursor in the treatment of cognitive impairment: Ineffective approaches or need for re-evaluation?”. Journal of the Neurological Sciences. 257 (1–2): 264–9.

(4). Journey to explore egt.

(5). Oleoylethanolamide (oea) –the magical wand of your life.

(6). Anandamide vs cbd: which one is better for your health? Everything you need to know about them!

(7). Everything you need to know about nicotinamide riboside chloride.

(8). Magnesium l-threonate supplements: benefits, dosage, and side effects.

(9). Palmitoylethanolamide (pea): benefits, dosage, uses, supplement.

(10). Top 6 health benefits of resveratrol supplements.

(11). Top 5 benefits of taking phosphatidylserine (ps).

(12). Top 5 benefits of taking pyrroloquinoline quinone (pqq).

(13). The best anti-aging supplement of nicotinamide mononucleotide(nmn).