Oleoylethanolamide (OEA) (111-58-0) video
Oleoylethanolamide (OEA) Specifications
|Molecular Weight:||325.53 g/mol|
|Melt Point:||59–60 °C|
|Synonyms:||N-Oleoylethanolamine, N-(Hydroxyethyl)oleamide, N-(cis-9-Octadecenoyl)ethanolamine, OEA|
|Solubility:||Soluble in DMSO, Methanol, Water|
|Storage Condition:||0 – 4 C for short term (days to weeks), or -20 C for long term (months)|
|Application:||Oleoylethanolamide (OEA) is a natural metabolite that is made in small amounts in your small intestine. OEA helps regulate hunger, weight, body fat and cholesterol by binding to a receptor known as PPAR-Alpha (Peroxisome proliferator-activated receptor alpha).|
What is Oleoylethanolamide (OEA) CAS 111-58-0?
Oleoylethanolamine (OEA) is a naturally occurring ethanolamide lipid and a nuclear receptor peroxisome proliferator-activated receptor-α (PPAR-α) agonist. It is produced in the small intestine and inhibits food intake via PPAR-α activation. OEA also activates GPR119, a bioactive lipid with hypophagic and anti-obesity effects.
Oleoylethanolamide (OEA) CAS 111-58-0 benefits
Oleoylethanolamide (OEA) is a natural metabolite that is made in small amounts in your small intestine. OEA helps regulate hunger, weight, body fat and cholesterol by binding to a receptor known as PPAR-Alpha (Peroxisome proliferator-activated receptor alpha). In essence, OEA increases the metabolism of body fat and tells your brain that you are full and it’s time to stop eating. OEA is also known to increase non-exercise related calorie expenditure.
Oleoylethanolamide (OEA) CAS 111-58-0 Mechanism Of Action?
Oleoylethanolamide (OEA) is synthesized and mobilized in the proximal small intestine from diet-derived oleic acid, such as olive oils. High-fat diet can inhibit OEA production in the intestine. OEA reduces food intake by activating homeostatic oxytocin and histamine brain circuitry as well as hedonic dopamine pathways. There is evidence that OEA may also attenuate hedonic cannabinoid receptor 1 (CB1R) signaling, the activation of which is associated with increased food intake. OEA reduces lipid transport into adipocytes to decrease fat mass. Further elucidation of the effects of OEA on food intake and lipid metabolism will aid in the determination of physiological mechanisms that can be targeted to develop more effective obesity therapies.
Oleoylethanolamide (OEA) is an agonist of peroxisome proliferator-activated receptor-α (PPAR-α). N-Oleoylethanolamide generates an intestinal signal that stimulates central dopamine activity establishing a link between caloric-homeostatic and hedonic-homeostatic controllers. Oleoylethanolamide has been implicated as the molecular mechanism associated with gastric bypass success. N-Oleoylethanolamide is a selective GPR55 agonist.
Oleoylethanolamide (OEA) CAS 111-58-0 Application
Oleoylethanolamide (OEA) works to activate something called PPAR and simultaneously ramps up fat-burning and decreases fat storage. When you eat, OEA levels increase and your appetite decreases when the sensory nerves that link to your brain tell it that you’re full. PPAR-α is a group of ligand-activated nuclear receptor that involved in the gene expression of lipid metabolism and energyhomeostasis pathways.
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- Gaetani S, Oveisi F, Piomelli D (2003). “Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamine”. Neuropsychopharmacology. 28 (7): 1311–6. doi:10.1038/sj.npp.1300166. PMID 12700681.
- Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). “Regulation of food intake by oleoylethanolamine”. Cell. Mol. Life Sci. 62 (6): 708–16. doi:10.1007/s00018-004-4494-0. PMID 15770421.
- Gaetani S, Kaye WH, Cuomo V, Piomelli D (September 2008). “Role of endocannabinoids and their analogues in obesity and eating disorders”. Eat Weight Disord. 13 (3): e42–8. PMID 19011363.